Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

نویسندگان

  • Lluis Palenzuela
  • Noah M Hahn
  • Robert P Nelson
  • Janet N Arno
  • Carol Schobert
  • Robert Bethel
  • Lisa A Ostrowski
  • Manjuli R Sharma
  • Partha P Datta
  • Rajendra K Agrawal
  • Jennifer E Schwartz
  • Michio Hirano
چکیده

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

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عنوان ژورنال:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

دوره 40 12  شماره 

صفحات  -

تاریخ انتشار 2005